{"created":"2023-05-15T14:34:56.179501+00:00","id":45152,"links":{},"metadata":{"_buckets":{"deposit":"72651827-507b-412f-9df1-c322ffadd502"},"_deposit":{"created_by":1,"id":"45152","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45152"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045152","sets":["1"]},"author_link":["448397","448396","448407","448408","448409","448398","448405","448403","448400","448402","448406","448399","448401","448404"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"436","bibliographicPageStart":"426","bibliographicVolumeNumber":"169","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation-induced thymic lymphoma in mice is a useful model for studying both the mechanism of radiation carcinogenesis and genetic susceptibility to tumor development. Using array-comparative genomic hybridization, we analyzed genome-wide changes in DNA copy numbers in radiation-induced thymic lymphomas that had developed in susceptible C57BL/6 and resistant C3H mice and their hybrids, C3B6F1 and B6C3F1 mice. Besides aberrations at known relevant genetic loci including Ikaros and Bcl11b and trisomy of chromosome 15, we identified strain-associated genomic imbalances on chromosomes 5, 10 and 16 and strain-unassociated trisomy of chromosome 14 as frequent aberrations. In addition, biallelic rearrangements at Tcrb were detected more frequently in tumors from C57BL/6 mice than in those from C3H mice, suggesting aberrant V(D)J recombination and a possible link with tumor susceptibility. The frequency and spectrum of these copy-number changes in lymphomas from C3B6F1 and B6C3F1 mice were similar to those in C57BL/6 mice. Furthermore, the loss of heterozygosity analyses of tumors in F1 mice indicated that allelic losses at Ikaros and Bcl11b were caused primarily by multilocus deletions, whereas those at the Cdkn2a/Cdkn2b and Pten loci were due mainly to uniparental disomy. These findings provide important clues to both the mechanisms for accumulation of aberrations during radiation-induced lymphomagenesis and the different susceptibilities of C57BL/6 and C3H mice.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1667/rr1180.1","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takabatake, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"448396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"448397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirouchi, Tokuhisa"}],"nameIdentifiers":[{"nameIdentifier":"448398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"M., Nakamura Masako"}],"nameIdentifiers":[{"nameIdentifier":"448399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujikawa, Katsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"448400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"448401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"448402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"448403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kimio"}],"nameIdentifiers":[{"nameIdentifier":"448404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高畠 貴志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 公夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448409","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of Changes in DNA Copy Number in Radiation-Induced Thymic Lymphomas of Susceptible C57BL/6, Resistant C3H and Hybrid F1 Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of Changes in DNA Copy Number in Radiation-Induced Thymic Lymphomas of Susceptible C57BL/6, Resistant C3H and Hybrid F1 Mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-07"},"publish_date":"2008-05-07","publish_status":"0","recid":"45152","relation_version_is_last":true,"title":["Analysis of Changes in DNA Copy Number in Radiation-Induced Thymic Lymphomas of Susceptible C57BL/6, Resistant C3H and Hybrid F1 Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:04.053223+00:00"}