{"created":"2023-05-15T14:34:55.847253+00:00","id":45147,"links":{},"metadata":{"_buckets":{"deposit":"96d0d530-877b-4bfe-bd66-acf8d41e90c0"},"_deposit":{"created_by":1,"id":"45147","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45147"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045147","sets":["1"]},"author_link":["448315","448319","448320","448314","448326","448322","448318","448327","448316","448328","448317","448329","448313","448323","448321","448312","448324","448311","448325"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"235","bibliographicPageStart":"229","bibliographicVolumeNumber":"197","bibliographic_titles":[{"bibliographic_title":"Psychopharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Rationale Paliperidone ER is a novel antipsychotic drug in an\nextended-release (ER) formulation.As with all antipsychotics,\ncareful dose setting is necessary to avoid side effects.\nObjectives In this study, we measured striatal and extrastriatal\ndopamine D2 receptor occupancy during paliperidone\nER treatment in patients with schizophrenia using\npositron emission tomography (PET) to compare regional\noccupancy and to estimate the optimal dose.\nMaterials and methods Thirteen male patients with schizophrenia\nparticipated in this 6-week multiple-dose study. Six\nof them took 3 mg of paliperidone ER per day, four took\n9 mg, and three took 15 mg. Two to 6 weeks after first drug\nintake, two PET scans, one with [11C]raclopride and one\nwith [11C]FLB 457, were performed in each patient on the\nsame day. The relationship between the dose or plasma\nconcentration of paliperidone and dopamine D2 receptor\noccupancy was calculated.\nResults The dopamine D2 receptor occupancies in the\nstriatum measured with [11C]raclopride and the temporal\ncortex measured with [11C]FLB 457 were 54.2–85.5% and\n34.5–87.3%, respectively. ED50 values of the striatum and\ntemporal cortex were 2.38 and 2.84 mg/day, respectively.\nThere was no significant difference in dopamine D2 receptor\noccupancy between the striatum and the temporal cortex.\nConclusions The data from this study suggest that paliperidone\nER at 6–9 mg provides an estimated level of\ndopamine D2 receptor occupancy between 70–80% and\nthat the magnitude of dopamine D2 receptor occupancy is\nsimilar between the striatum and temporal cortex.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-3158","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arakawa, Ryosuke"}],"nameIdentifiers":[{"nameIdentifier":"448311","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"448312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"448313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"448314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimoto, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"448315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sassa, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"448316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohta, Katsuya"}],"nameIdentifiers":[{"nameIdentifier":"448317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Motoichiro"}],"nameIdentifiers":[{"nameIdentifier":"448318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okubo, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"448319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"448320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晶寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森本 卓哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々 毅","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 元一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 善朗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448329","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-07"},"publish_date":"2008-05-07","publish_status":"0","recid":"45147","relation_version_is_last":true,"title":["Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:07.825124+00:00"}