{"created":"2023-05-15T14:34:54.457826+00:00","id":45126,"links":{},"metadata":{"_buckets":{"deposit":"7693ea49-5587-4bbf-ba34-d8f404fa0f6d"},"_deposit":{"created_by":1,"id":"45126","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45126"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045126","sets":["1"]},"author_link":["448138","448137"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"421","bibliographicPageStart":"417","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Methods and Findings in Experimental and Clinical Pharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The discovery of RNA interference (RNAi) in mammalian cells raises the expectations of gene therapy, especially in cancer. However, it is too early to say how great this promise may be because of many disputable problems including intracellular delivery of siRNA, the transient nature of RNAi and potential side effects after long-term treatment. The present microarray study demonstrates that the RNAi of one oncogene (encoding bcr-abl fusion protein in chronic myelogenous leukemia) triggers an overexpression of other \"sleeping\" oncogenes, antiapoptotic genes and factors, preserving the immortalization of bcr-abl-positive leukemia cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0379-0355","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bakalova-Zheleva, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"448137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448138","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"RNA interference - about the reality to be exploited in cancer therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNA interference - about the reality to be exploited in cancer therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-25"},"publish_date":"2008-03-25","publish_status":"0","recid":"45126","relation_version_is_last":true,"title":["RNA interference - about the reality to be exploited in cancer therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:22.828241+00:00"}