@article{oai:repo.qst.go.jp:00045114,
 author = {柳, 剛 and 恩田, 健志 and 別所, 央城 and 高木, 亮 and 長谷川, 安都佐 and 溝江, 純悦 and 花澤, 豊行 and 岡本, 美孝 and 辻井, 博彦 and 柳 剛 and 恩田 健志 and 別所 央城 and 高木 亮 and 長谷川 安都佐 and 溝江 純悦 and 花澤 豊行 and 岡本 美孝 and 辻井 博彦},
 issue = {4},
 journal = {The Journal of JASTRO = 日本放射線腫瘍学会誌},
 month = {Dec},
 note = {Recent treatment of the photon radiotherapy for hypopharyngeal carcinoma have made significant improvement with more intensive methods such as accelerated hyperfractionation or combination with chemotherapy. As intensity of the therapy increased, adverse normal tissue reactions developed. To improve these conditions, we started carbon ion radiotherapy with concomitant weekly cisplatin. This is a preliminary report of concomitant chemoradiotherapy with carbon ion beams for hypopharyngeal carcinoma. The design of the protocol was phase I/II dose escalation study. The starting dose-fractionation schedule was 57.6 GyE/16 fractions/4W (3.6 GyE per fraction). The target volume included the primary tumor, infiltrated lymph nodes, and prophylactic bilateral cervical lymphatics. Cisplatin 30 mg/m2 were concomitantly administered during the treatment on day 1,8,15,22. All treatments were given for 4 weeks. Between September 2004 and August 2006, 7 patients were registered. Five patients were diagnosed with Stage III, and 2 with Stage IV. Three patients received 57.6 GyE, and four patients 60.8 GyE. The median follow-up period was 10.4 months. No severe acute reactions were seen. At eigh months from the start of the treatment, one patient developed grade 3 edema in his larynx (RTOG/EORTC). As for the local control, one patient developed local recurrence, and the salvaged surgery freed this patient from the disease. The preliminary report of Phase I/II was provided; Phase I/II studied the dose escalation of carbon ion radiotherapy for hypopharyngeal carcinoma. Further research is needed.},
 pages = {297--302},
 title = {下咽頭癌に対する化学療法同時併用重粒子線治療-preliminary report-},
 volume = {19},
 year = {2007}
}