@article{oai:repo.qst.go.jp:00045113,
 author = {Kato, Takamitsu and Okayasu, Ryuichi and S., Bedford Joel and 加藤 宝光 and 岡安 隆一},
 issue = {1/2},
 journal = {Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research},
 month = {Mar},
 note = {The induction and disappearance of DNA double strand breaks (DSBs) after
irradiation of G1 and mitotic cells were compared with the gamma-H2AX foci
assay and a gel electrophoresis assay. This is to determine whether cell
cycle related changes in chromatin structure might influence the gamma-H2AX
assay which depends on extensive phosphorylation and dephosphorylation of
the H2AX histone variant surrounding DSBs. The disappearance of gamma-H2AX foci
after irradiation was much slower for mitotic than for G1 cells. On the
other hand, no difference was seen for the gel electrophoresis assay. Our
data may suggest the limited accessibility of dephosphorylation enzyme in
irradiated metaphase cells or trapped gamma-H2AX in condensed chromatin.},
 pages = {108--112},
 title = {Comparison of the iInduction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells},
 volume = {639},
 year = {2008}
}