@article{oai:repo.qst.go.jp:00045112,
 author = {Asai, Yoshiyuki and Takano, Akihiro and Ito, Hiroshi and Okubo, Yoshiro and Matsuura, Masato and Takahashi, Hidehiko and Arakawa, Ryosuke and Asai, Kunihiko and Suhara, Tetsuya and et.al and 浅井 禎之 and 高野 晶寛 and 伊藤 浩 and 大久保 善朗 and 高橋 英彦 and 荒川 亮介 and 須原 哲也},
 issue = {1/3},
 journal = {Schizophrenia Research},
 month = {Feb},
 note = {Dysfunction of the GABA system is considered to play a role in the pathology of schizophrenia. Individual subunits of GABAA/Benzodiazepine (BZ) receptor complex have been revealed to have different functional properties. [alpha]5 subunit was reported to be related to learning and memory. Changes of [alpha]5 subunit in schizophrenia were reported in postmortem studies, but the results were inconsistent. In this study, we examined GABAA/BZ receptor using [11C]Ro15-4513, which has relatively high affinity for [alpha]5 subunit, and its relation to clinical symptoms in patients with schizophrenia.
\n[11C]Ro15-4513 bindings of 11 patients with schizophrenia (6 drug-naïve and 5 drug-free) were compared with those of 12 age-matched healthy control subjects using positron emission tomography. Symptoms were assessed using the Positive and Negative Syndrome Scale. [11C]Ro15-4513 binding was quantified by binding potential (BP) obtained by the reference tissue model. [11C]Ro15-4513 binding in the prefrontal cortex and hippocampus was negatively correlated with negative symptom scores in patients with schizophrenia, although there was no significant difference in BP between patients and controls. GABAA/BZ receptor including [alpha]5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia.},
 pages = {333--340},
 title = {GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for [alpha]5 subunit},
 volume = {99},
 year = {2008}
}