{"created":"2023-05-15T14:34:52.844558+00:00","id":45098,"links":{},"metadata":{"_buckets":{"deposit":"b11208f8-91b4-4bca-a27a-3b4b4ffcc371"},"_deposit":{"created_by":1,"id":"45098","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45098"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045098","sets":["1"]},"author_link":["447845","447847","447850","447848","447846","447849"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"52","bibliographicPageStart":"43","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"NeuroImage"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The peripheral benzodiazepine receptor (PBR) is upregulated on\nactivated microglia and macrophages and thereby is a useful biomarker\nof inflammation. We developed a novel PET radioligand, [11C]PBR28,\nthat was able to image and quantify PBRs in healthy monkeys and in a\nrat model of stroke. The objective of this study was to evaluate the ability\nof [11C]PBR28 to quantify PBRs in brain of healthy human subjects.\nTwelve subjects had PET scans of 120 to 180 min duration as well as\nserial sampling of arterial plasma to measure the concentration of\nunchanged parent radioligand. One- and two-tissue compartmental\nanalyses were performed. To obtain stable estimates of distribution\nvolume, which is a summation of Bmax/KD and nondisplaceable activity,\n90 min of brain imaging was required. Distribution volumes in human\nwere only ~5% of those in monkey. This comparatively low amount of\nreceptor binding required a two-rather than a one-compartment model,\nsuggesting that nonspecific binding was a sizeable percentage compared\nto specific binding. The time-activity curves in two of the twelve subjects\nappeared as if they had no PBR binding—i.e., rapid peak of uptake and\nfast washout from brain. The cause(s) of these unusual findings are\nunknown, but both subjects were also found to lack binding to PBRs in\nperipheral organs such as lung and kidney. In conclusion, with the\nexception of those subjects who appeared to have no PBR binding, [11C]\nPBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1053-8119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"447845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimura, Yota"}],"nameIdentifiers":[{"nameIdentifier":"447846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"447847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"447848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤村 洋太","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447850","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Kinetic Analysis in Healthy Humans of a Novel Positron Emission Tomography Radioligand to Image the Peripheral Benzodiazepine Receptor, a Potential Biomarker for Inflammation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Kinetic Analysis in Healthy Humans of a Novel Positron Emission Tomography Radioligand to Image the Peripheral Benzodiazepine Receptor, a Potential Biomarker for Inflammation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-02-26"},"publish_date":"2008-02-26","publish_status":"0","recid":"45098","relation_version_is_last":true,"title":["Kinetic Analysis in Healthy Humans of a Novel Positron Emission Tomography Radioligand to Image the Peripheral Benzodiazepine Receptor, a Potential Biomarker for Inflammation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:43.364956+00:00"}