@article{oai:repo.qst.go.jp:00045094,
 author = {Mahasittiwat, Pawinee and Mizoe, Junetsu and Hasegawa, Azusa and Ishikawa, Hiroyuki and Yoshikawa, Kyosan and Mizuno, Hideyuki and Yanagi, Takeshi and Takagi, Ryo and Pattaranutaporn, Pittyapoom and Tsujii, Hirohiko and 溝江 純悦 and 長谷川 安都佐 and 石川 博之 and 吉川 京燦 and 水野 秀之 and 柳 剛 and 高木 亮 and 辻井 博彦},
 issue = {2},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Sep},
 note = {PURPOSE: To assess the importance of (11)C-methionine (MET)-positron emission tomography (PET) for clinical target volume (CTV) delineation. METHODS AND MATERIALS: This retrospective study analyzed 16 patients with malignant glioma (4 patients, anaplastic astrocytoma; 12 patients, glioblastoma multiforme) treated with surgery and carbon ion radiotherapy from April 2002 to Nov 2005. The MET-PET target volume was compared with gross tumor volume and CTV, defined by using computed tomography/magnetic resonance imaging (MRI). Correlations with treatment results were evaluated between positive and negative extended volumes (EVs) of the MET-PET target for CTV. RESULTS: Mean volumes of the MET-PET targets, CTV1 (defined by means of high-intensity volume on T2-weighted MRI), and CTV2 (defined by means of contrast-enhancement volume on T1-weighted MRI) were 6.35, 264.7, and 117.7 cm(3), respectively. Mean EVs of MET-PET targets for CTV1 and CTV2 were 0.6 and 2.2 cm(3), respectively. The MET-PET target volumes were included in CTV1 and CTV2 in 13 (81.3%) and 11 patients (68.8%), respectively. Patients with a negative EV for CTV1 had significantly greater survival rate (p = 0.0069), regional control (p = 0.0047), and distant control time (p = 0.0267) than those with a positive EV. Distant control time also was better in patients with a negative EV for CTV2 than those with a positive EV (p = 0.0401). CONCLUSIONS: For patients with malignant gliomas, MET-PET has a possibility to be a predictor of outcome in carbon ion radiotherapy. Direct use of MET-PET fused to planning computed tomography will be useful and yield favorable results for the therapy.},
 pages = {515--522},
 title = {L-[methyl-11C] Methionine positron emission tomography for target delineation in malignant gliomas: impact on results of carbon ion radiotherapy.},
 volume = {70},
 year = {2007}
}