{"created":"2023-05-15T14:34:51.374857+00:00","id":45064,"links":{},"metadata":{"_buckets":{"deposit":"19925eac-7335-48ec-80c9-2dfbd663b4e8"},"_deposit":{"created_by":1,"id":"45064","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45064"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045064","sets":["1"]},"author_link":["447488","447489","447490","447499","447500","447486","447494","447496","447493","447498","447495","447491","447497","447487","447492"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"2131","bibliographicPageStart":"2118","bibliographicVolumeNumber":"102","bibliographic_titles":[{"bibliographic_title":"Journal of Neurochemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activated microglia are an important feature of many neurological diseases and can be imaged in vivo using 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195), a ligand that binds the peripheral benzodiazepine receptor (PBR). N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl) acetamide (DAA1106) is a new PBR-specific ligand that has been reported to bind to PBR with higher affinity compared with PK11195. We hypothesized that this high-affinity binding of DAA1106 to PBR will enable better delineation of microglia in vivo using positron emission tomography. [3H]DAA1106 showed higher binding affinity compared with [3H](R)-PK11195 in brain tissue derived from normal rats and the rats injected intrastriatally with 6-hydroxydopamine or lipopolysaccharide at the site of the lesion. Immunohistochemistry combined with autoradiography in brain tissues as well as correlation analyses showed that increased [3H]DAA1106 binding corresponded mainly to activated microglia. Finally, ex vivo autoradiography and positron emission tomography imaging in vivo showed greater retention of [11C]DAA1106 compared with [11C](R)-PK11195 in animals injected with either lipopolysaccaride or 6-hydroxydopamine at the site of lesion. These results indicate that DAA1106 binds with higher affinity to microglia in rat models of neuroinflammation when compared with PK11195, suggesting that [11C]DAA1106 may represent a significant improvement over [11C](R)-PK11195 for in vivo imaging of activated microglia in human neuroinflammatory disorders.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-3042","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Venneti, Sriram"}],"nameIdentifiers":[{"nameIdentifier":"447486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lopresti, Brian"}],"nameIdentifiers":[{"nameIdentifier":"447487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Guoji"}],"nameIdentifiers":[{"nameIdentifier":"447488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Slagel, Susan"}],"nameIdentifiers":[{"nameIdentifier":"447489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Scott, Mason N."}],"nameIdentifiers":[{"nameIdentifier":"447490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mathis, Chester"}],"nameIdentifiers":[{"nameIdentifier":"447491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fischer, Michelle"}],"nameIdentifiers":[{"nameIdentifier":"447492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Larsen, Niccole"}],"nameIdentifiers":[{"nameIdentifier":"447493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Smith, Amanda"}],"nameIdentifiers":[{"nameIdentifier":"447494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hastings, Teresa"}],"nameIdentifiers":[{"nameIdentifier":"447495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"447496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"447497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wiley, Clayton"}],"nameIdentifiers":[{"nameIdentifier":"447498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447500","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106and(R)-PK11195 in rat models of neuroinflammation:implications for PET imaging of microglial activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106and(R)-PK11195 in rat models of neuroinflammation:implications for PET imaging of microglial activation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-07"},"publish_date":"2008-01-07","publish_status":"0","recid":"45064","relation_version_is_last":true,"title":["A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106and(R)-PK11195 in rat models of neuroinflammation:implications for PET imaging of microglial activation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:08:07.286352+00:00"}