@article{oai:repo.qst.go.jp:00045007,
 author = {Maruyama, Kouichi and Ishikawa, Yuji and Yasumasu, Shigeki and Iuchi, Ichiro and Kouichi, Maruyama and Yuuji, Ishikawa and Shigeki, Yasumasu},
 issue = {10},
 journal = {Zoological Science},
 month = {Oct},
 note = {In medaka, we found a C16orf35 gene-like gene at the 1Kbp-3'downstream
region of the yb end of the 36Kbp embryonic globin gene cluster
(5'a03'-3'b15'-5'a13'-5'b23'-5'a23'-3'a35'-5'b33'-3'b45'-5'a43'-3'ya5'-5'yb3
'). Intron 5 of the gene contained a region having NF-E2 binding sites
located between GATA boxes. The region was homologous to human HS-40 in the
existence and structure of characteristic transcription factor binding sites
and was named Ol-HS-40. Injection of the fusion gene construct
(Ol-HS-40-a0(up-2)GFP) consisting of Ol-HS-40, a 200bp-5'upstream minimum
promoter for a0, and GFP showed that Ol-HS-40, as in human HS-40, had the
ability to strongly enhance GFP expression in erythroid cells of embryos.
Further analysis using transgenic technology revealed that Ol-HS-40 had the
ability to change the embryo-to-young fish expression of GFP into the
embryo-to-adult expression. In addition, the results suggest that Ol-HS-40,
although its natural function remains unclear, has the strong enhancer
activity for the expression of not only the a-globin gene but also the
b-globin gene.},
 pages = {997--1004},
 title = {Globin Gene Enhancer Activity of DNase-I Hypersensitive Site-40 Homolog in Medaka, Oryzias latipes},
 volume = {24},
 year = {2007}
}