@article{oai:repo.qst.go.jp:00045004,
 author = {Kawano, Akihiro and Ikeda, Manabu and Iritani, Riichirou and Kinoshita, Akiko and Watanabe, Kaori and Hayao, Tatsuo and Kokubo, Toshiaki and Matsushita, Satoru and 河野 明広 and 池田 学 and 入谷 理一郎 and 舘野 香里 and 早尾 辰雄 and 小久保 年章 and 松下 悟},
 issue = {9},
 journal = {Journal of Veterinary Medical Science},
 month = {Sep},
 note = {Soft feces and a decreased delivery rate were observed in a specific pathogen-free (SPF) C3H-scid mouse breeding colony. Grossly, the ceca were shrunken and edematous in the affected mice. Histopathologically, severe edema in the cecal submucosa as well as infiltration of inflammatory cells in the lamina propria and submucosa of the ceca and colon were observed. No pathogenic microorganisms were detected by the routine microbiological tests. By anaerobic bacterial-examination, Clostridium (C.) difficile with toxin A was isolated from the cecal contents of the affected mice. The present mice were diagnosed as C. difficile-associated colitis. This case appears to be the first report of natural infection with C. difficile in SPF mice with clinical signs.},
 pages = {973--975},
 title = {Colitis associated with Clostridium difficile in specific-pathogen-free C3H-scid mice},
 volume = {69},
 year = {2007}
}