@article{oai:repo.qst.go.jp:00044998,
 author = {Noda, Shinei and Ohno, Tatsuya and Kato, Shingo and Ishii, Takayoshi and Saitou, Osami and Wakatuki, Masaru and Tamaki, Tomoaki and Watanabe, Kazuhiro and Nakano, Takashi and Tsujii, Hirohiko and 大野 達也 and 加藤 眞吾 and 石居 隆義 and 斉藤 収三 and 若月 優 and 田巻 倫明 and 渡邊 和洋 and 中野 隆史 and 辻井 博彦},
 issue = {1},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Feb},
 note = {Purpose: To investigate the efficacy of dose calculations at the computed tomography (CT)-based rectal point (CTRP) as a predictive factor for late rectal complications in patients with cervical carcinoma who were treated with a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy.
\nMethods and Materials: Ninety-two patients with uterine cervical carcinoma undergoing definitive radiotherapy alone were retrospectively analyzed. The median follow-up time for all patients was 32 months (range, 13–60 months). The cumulative biologically effective dose (BED) was calculated at the rectal reference point as defined by the International Commission on Radiation Units and Measurements Report 38 (BEDRP) and at the CTRP (BEDCTRP). Late rectal complications were recorded according to the Radiation Therapy Oncology Group grading system.
\nResults: The late rectal complications were distributed as follows: Grade 0, 68 patients (74%); Grade 1, 20 patients (22%); Grade 2, 4 patients (4%). Univariate analysis showed that BEDRP, BEDCTRP, RP dose/point A dose ratio, and CTRP dose/point A dose ratio were significantly correlated with late rectal complications (p < 0.05). On multivariate analysis, patients with a rectal BEDCTRP &#8805;140 Gy3 presented with significantly greater frequency of rectal complications (p = 0.031).
\nConclusions: The present results suggest that BEDCTRP is a useful predictive factor for late rectal complications.},
 pages = {118--124},
 title = {Late Rectal Complications Evaluated by computed tomography-Based Dose Calculations in Patients with Cervical carcinoma Undergoing high-Dose-rate Brachytherapy},
 volume = {69},
 year = {2007}
}