{"created":"2023-05-15T14:34:47.332514+00:00","id":44970,"links":{},"metadata":{"_buckets":{"deposit":"df740e49-348b-4402-8425-f41e3c0102a1"},"_deposit":{"created_by":1,"id":"44970","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44970"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044970","sets":["1"]},"author_link":["446568","446565","446572","446564","446569","446563","446566","446567","446570","446571"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"152","bibliographicPageStart":"143","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"p53 is one of the most frequently mutated genes in mammary carcinomas (MCs). To detect tumor suppressor genes cooperating with a hetero-deficient p53 gene in mammary carcinogenesis, we first examined allelotypes in MCs from (BALB/cHeA x MSM/Ms) F(1)- p53(+/-) and (BALB/cHeA x 129/SvEv) F(1)- p53(+/-) female mice, and then surveyed down-regulated genes in the allelic loss regions. Genome-wide screening at 42 loci identified frequent (more than 30%) loss of heterozygosity (LOH) on chromosomes 5, 8, 11, 12, 14 and 18 in the MCs from either of the F(1) mice. The MCs in the p53(+/- )mice indicated highly frequent LOH, especially on chromosomes 8, 11 and 12, distinct from other mouse tumors. More than 60% of the 38 MCs from (BALB/cHeA x MSM/Ms) F(1)- p53 (+/-) mice showed LOH in a region ranging from D8Mit85 (105.0 Mb from centromere) to D8Mit113 (111.8 Mb) on chromosome 8, a region syntenic to human chromosome 16q22.1, on which LOH has been found in breast cancers. RT-PCR analyses revealed that the LOH of chromosome 8 was associated with the reduced and/or complete loss of expression of Cdh1 and Cdh5 genes in 15 (58%) and 8 (31%) of 26 MCs derived from the F(1) mice, respectively. Thus, inactivation of Cdh1 and Cdh5 is likely to cooperate with the loss of p53, suggesting a possible tumor suppressive function of these genes in mammary carcinogenesis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Umesako, Seiichi"}],"nameIdentifiers":[{"nameIdentifier":"446563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iiga, Sayoko"}],"nameIdentifiers":[{"nameIdentifier":"446564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"446565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imura, Kae"}],"nameIdentifiers":[{"nameIdentifier":"446566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Nobuko"}],"nameIdentifiers":[{"nameIdentifier":"446567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Pyo, Hong Doo"}],"nameIdentifiers":[{"nameIdentifier":"446568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Song, Cheng-woo"}],"nameIdentifiers":[{"nameIdentifier":"446569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Ohtsura"}],"nameIdentifiers":[{"nameIdentifier":"446570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumoto, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"446571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丹羽 太貫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446572","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinct Pattern of Allelic Loss and Inactivation of Cadherin 1 and 5 Genes in Mammary Carcinomas Arising in p53+/-Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinct Pattern of Allelic Loss and Inactivation of Cadherin 1 and 5 Genes in Mammary Carcinomas Arising in p53+/-Mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-09-06"},"publish_date":"2007-09-06","publish_status":"0","recid":"44970","relation_version_is_last":true,"title":["Distinct Pattern of Allelic Loss and Inactivation of Cadherin 1 and 5 Genes in Mammary Carcinomas Arising in p53+/-Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:09:12.119181+00:00"}