@article{oai:repo.qst.go.jp:00044963,
 author = {Ito, Hiroshi and Shidahara, Miho and Takano, Harumasa and Takahashi, Hidehiko and Nozaki, Syoko and Suhara, Tetsuya and 伊藤 浩 and 志田原 美保 and 高野 晴成 and 高橋 英彦 and 野崎 昭子 and 須原 哲也},
 issue = {6},
 journal = {Annals of Nuclear Medicine},
 month = {Aug},
 note = {Objective The lung is one of the key organs for determining
the distribution of drugs in the human body.
Various factors infl uence the accumulation of drugs. In
this study, we investigated the effects of smoking on drug
distribution to the lung using radiolabeled drugs.
Methods We measured the lung uptake of [11C]
(+)McN5652, a radioligand for serotonin transporter
(5-HTT), and inactive enantiomer [11C](−)McN5652 in
19 healthy men (12 nonsmokers and 7 smokers) using
positron emission tomography. Pretreatment study was
performed by the administration of clomipramine
(50 mg), a potent 5-HTT inhibitor.
Results The mean lung uptake of [11C](+)McN5652 and
[11C](−)McN5652 was signifi cantly higher in smokers
than in nonsmokers. The lung uptake of [11C](+)McN5652
decreased after pretreatment with clomipramine, whereas
that of [11C](−)McN5652 was not affected by
clomipramine.
Conclusions Lung uptake of [11C](−)McN5652 was
in fl uenced by smoking, possibly because the probable
nonspecifi c binding accumulation was changed as [11C]
(−)McN5652 was reported to have negligible affi nity to
5-HTT. Smoking might be one of the important factors
when distribution of radioligands is considered.},
 pages = {355--360},
 title = {Mapping of Central Dopamine Synthesis in Man using Positron Emission Tomography with L-[beta-11C]DOPA},
 volume = {21},
 year = {2007}
}