{"created":"2023-05-15T14:34:46.986797+00:00","id":44962,"links":{},"metadata":{"_buckets":{"deposit":"e9daf45d-2331-47b1-ab71-233d193c401a"},"_deposit":{"created_by":1,"id":"44962","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44962"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044962","sets":["1"]},"author_link":["446508","446514","446512","446511","446513","446510","446506","446516","446507","446515","446509"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"354","bibliographicPageStart":"349","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective The lung is one of the key organs for determining\nthe distribution of drugs in the human body.\nVarious factors infl uence the accumulation of drugs. In\nthis study, we investigated the effects of smoking on drug\ndistribution to the lung using radiolabeled drugs.\nMethods We measured the lung uptake of [11C]\n(+)McN5652, a radioligand for serotonin transporter\n(5-HTT), and inactive enantiomer [11C](−)McN5652 in\n19 healthy men (12 nonsmokers and 7 smokers) using\npositron emission tomography. Pretreatment study was\nperformed by the administration of clomipramine\n(50 mg), a potent 5-HTT inhibitor.\nResults The mean lung uptake of [11C](+)McN5652 and\n[11C](−)McN5652 was signifi cantly higher in smokers\nthan in nonsmokers. The lung uptake of [11C](+)McN5652\ndecreased after pretreatment with clomipramine, whereas\nthat of [11C](−)McN5652 was not affected by\nclomipramine.\nConclusions Lung uptake of [11C](−)McN5652 was\nin fl uenced by smoking, possibly because the probable\nnonspecifi c binding accumulation was changed as [11C]\n(−)McN5652 was reported to have negligible affi nity to\n5-HTT. Smoking might be one of the important factors\nwhen distribution of radioligands is considered","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takano, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"446506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"446507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichimiya, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"446508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"446509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"446510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"446511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晶寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"一宮 哲哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446516","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of smoking on the lung accumulation of [11C]McN5652","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of smoking on the lung accumulation of [11C]McN5652"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-09-05"},"publish_date":"2007-09-05","publish_status":"0","recid":"44962","relation_version_is_last":true,"title":["Effects of smoking on the lung accumulation of [11C]McN5652"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:09:17.685284+00:00"}