{"created":"2023-05-15T14:34:45.732136+00:00","id":44933,"links":{},"metadata":{"_buckets":{"deposit":"f61aa91f-b4d5-4f59-9e97-16e0ea91319e"},"_deposit":{"created_by":1,"id":"44933","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44933"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044933","sets":["1"]},"author_link":["446236","446231","446237","446232","446240","446243","446228","446226","446227","446239","446242","446229","446244","446245","446235","446230","446234","446233","446238","446241"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"562","bibliographicPageStart":"550","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Advances in Space Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"With a significant increase in human activities dealing with space\nmissions, potential teratogenic effects on the mammalian reproductive system\nfrom prenatal exposure to space radiation have become a hot topic that needs\nto be addressed. However, even for the ground experiments, such effects from\nexposure to high LET ionizing radiation are not as well studied as those for\nlow LET ionizing radiations such as X-rays. Using the Heavy Ion Medical\nAccelerator in Chiba (HIMAC) and Wistar rats, effects on gonads in prenatal\nmale fetuses, on postnatal testicular development and on breeding activity\nof male offspring were studied following exposure of the pregnant animals to\neither accelerated carbon-ion beams with a LET value of about 13 keV/microm or\nneon-ion beams with a LET value of about 30 keV/microm at a dose range from 0.1\nGy to 2.0 Gy on gestation day 15. The effects of X-rays at 200 kVp estimated\nfor the same biological end points were studied for comparison. A\nsignificantly dose-dependent increase of apoptosis in gonocytes appeared 6\nhours after irradiations with a dose of 0.5 Gy or more. Measured delayed\ntestis descent and malformed testicular seminiferous tubules were observed\nto be significantly different from the control animals at a dose of 0.5 Gy.\nThese effects are observed to be dose- and LET- dependent. Markedly reduced\ntesticular weight and testicular weight to body weight ratio were scored at\npostnatal day 30 even in the offspring that were prenatally irradiated with\neon ions at a dose of 0.1 Gy. A dose of 0.5 Gy from neon-ion beams induced a\nmarked decrease in breeding activity in the prenatally irradiated male rats,\nwhile for the carbon-ion beams or X-rays, the significantly reduced breeding\nactivity was observed only when the prenatal dose was at 1.0 Gy or more.\nThese findings indicated that prenatal irradiations with heavy ion beams on\ngestation day 15 generally induced markedly detrimental effects on prenatal\ngonads, postnatal testicular development and male breeding activity in rats,\nwhich seemed to be a dose and LET-related event.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0273-1177","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"446226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"446227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"446228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojima, Kumie"}],"nameIdentifiers":[{"nameIdentifier":"446229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"446230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"446231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"446232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"446233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moreno, Stephanie.G"}],"nameIdentifiers":[{"nameIdentifier":"446234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Herve, Coffigny"}],"nameIdentifiers":[{"nameIdentifier":"446235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"446236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 恵子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446245","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of prenatal irradiation with accelerated heavy-ion beams on postnatal development in rats : III.Testicular development and breeding activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of prenatal irradiation with accelerated heavy-ion beams on postnatal development in rats : III.Testicular development and breeding activity"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-08-03"},"publish_date":"2007-08-03","publish_status":"0","recid":"44933","relation_version_is_last":true,"title":["Effects of prenatal irradiation with accelerated heavy-ion beams on postnatal development in rats : III.Testicular development and breeding activity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:09:38.055417+00:00"}