{"created":"2023-05-15T14:34:44.904629+00:00","id":44914,"links":{},"metadata":{"_buckets":{"deposit":"2ef11e77-61ef-4bf1-a6be-f1dd10914ef8"},"_deposit":{"created_by":1,"id":"44914","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44914"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044914","sets":["1"]},"author_link":["446100","446098","446099","446096","446102","446095","446101","446097"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"750","bibliographicPageStart":"743","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We studied the regional characteristics within tumor masses using PET tracers and immunohistochemical methods.\nMethods: The intratumoral distribution of 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM) and [18F] 2-fluoro-2-\ndeoxyglucose (18F]FDG) in mice with tumors of four different origins (LLC1, Meth-A, B16 and colon26) was compared with the\nimmunohistochemical staining of proliferating cells (Ki67), blood vessels (CD34 or von Willebrand factor), and apoptotic cells (terminal\ndeoxynucleotidyltransferase-mediated dUTP nick end labeling method).\nResults: With all cell lines, [64Cu]Cu-ATSM and [18F]FDG were distributed with different gradation in the tumor mass. The\nimmunohistochemical study demonstrated that the high [64Cu]Cu-ATSM uptake regions were hypovascular and consisted of tumor cells\narrested in the cell cycle, whereas the high [18F]FDG uptake regions were hypervascular and consisted of proliferating cells.\nConclusion: In our study, it was revealed that one tumor mass contained two regions with different characteristics, which could be\ndistinguished by [64Cu]Cu-ATSM and [18F]FDG. Because hypoxia and cell cycle arrest are critical factors to reduce tumor sensitivity to\nradiation and conventional chemotherapy, regions with such characteristics should be treated intensively as one of the primary targets.\n[64Cu]Cu-ATSM, which can delineate hypoxic and cell cycle-arrested regions in tumors, may provide valuable information for cancer\ntreatment as well as possibly for treating such regions directly as an internal radiotherapy reagent.\nD 2006 Elsevier Inc. All rights reserved.\nKeywords: Cu-ATSM; FDG; Hypoxia; Immunohistochemistry; Cancer imaging","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"446095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"446096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yonekura, Yoshiharu"}],"nameIdentifiers":[{"nameIdentifier":"446097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujibayashi, Yasuhisa"}],"nameIdentifiers":[{"nameIdentifier":"446098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"446099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"米倉 義晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"446102","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-07-05"},"publish_date":"2007-07-05","publish_status":"0","recid":"44914","relation_version_is_last":true,"title":["Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:09:51.857216+00:00"}