{"created":"2023-05-15T14:34:43.605037+00:00","id":44884,"links":{},"metadata":{"_buckets":{"deposit":"6accf7d7-5a74-4c35-8d20-1f8a1f19d1f6"},"_deposit":{"created_by":1,"id":"44884","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44884"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044884","sets":["1"]},"author_link":["445808","445804","445807","445803","445805","445806"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"120","bibliographicPageStart":"116","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Clinical Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE: The purpose of this study is to clarify the efficacy and toxicity of hyperfractionated radiation therapy (RT) for patients with nasopharyngeal cancer (NPC). METHODS: Twenty-two patients with NPC treated at our hospital between April 1994 and December 2002 were the subjects of this study. They received hyperfractionated RT with a fraction size of 1.2 Gy, with a median tumor dose of 72 Gy (range 64.8-80.4). During this study period, our institutional strategy for locoregionally advanced NPC included neoadjuvant or concurrent chemotherapy combined with hyperfractionated RT, and 17 patients received some forms of cisplatin-containing chemotherapy. RESULTS: With a median follow-up of 59 months, the estimated 5-year disease-free survival rate and overall survival rate were 72.7 and 85.2%, respectively. Acute hematological toxicities were acceptable and manageable. However, >50% of patients required nutritional support, and experienced severe pharyngitis, skin reaction and body weight loss. With regard to late sequelae, one patient developed grade 3 osteomyelitis, and one patient each developed grade 4 passage disturbance and laryngeal edema. No patients experienced any grades of optic nerve injury or temporal lobe necrosis. CONCLUSIONS: Hyperfractionated RT using 1.2 Gy per fraction, for a total dose of 72 Gy, produces a comparable treatment outcome. Although deleterious neurological sequelae were not observed in this study, caution should be exercised regarding other late sequelae, such as osteomyelitis and passage disturbance.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0368-2811","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uno, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"445803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"445804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"445805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇野 隆","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊東 久夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445808","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hyperfractionated Radiation Therapy for Locoregionally Advanced Nasopharyngeal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hyperfractionated Radiation Therapy for Locoregionally Advanced Nasopharyngeal Cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-06-18"},"publish_date":"2007-06-18","publish_status":"0","recid":"44884","relation_version_is_last":true,"title":["Hyperfractionated Radiation Therapy for Locoregionally Advanced Nasopharyngeal Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:10:12.764134+00:00"}