{"created":"2023-05-15T14:34:43.562001+00:00","id":44883,"links":{},"metadata":{"_buckets":{"deposit":"3969c676-b38b-4445-a30d-09f74d05c1d3"},"_deposit":{"created_by":1,"id":"44883","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44883"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044883","sets":["1"]},"author_link":["445788","445789","445797","445787","445799","445791","445785","445790","445798","445793","445795","445796","445801","445792","445784","445794","445802","445800","445783","445786"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1003","bibliographicPageStart":"994","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Advances in Space Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Organogenesis is a highly radiosensitive period, study of prenatal exposure\nto high LET heavy ion beams on postnatal development is important for\nclarifying the radiation risk in space and promoting the evidence-based\nmechanism research. The effects from heavy ion irradiations are not well\nstudied as those for low LET radiations such as X-rays in this field, even\nthe ground-based investigations remain to be addressed. Using the Heavy Ion\nMedical Accelerator in Chiba (HIMAC) and Wistar rats, postnatal\nneurophysiological development in offspring was investigated following\nexposure of pregnant rats to accelerated neon-ion beams with a LET value of\nabout 30 keV/um at a dose range from 0.1 to 2.0Gy on the 15th day of\ngestation. The age for appearance of four physiologic markers and attainment\nof five neonatal reflexes, and gain in body weight were monitored. Male\noffspring were evaluated as young adults using two behavioral tests\nincluding open field and hole-board dipping tests. The effects of X-rays at\n200 kVp measured for the same biological end points were studied for\ncomparison. For most of the endpoints at early age, significant\nneurophysiological alteration was observed even in offspring receiving 0.1\nGy of accelerated neon ions but not X-rays. All offspring receiving 2.0 Gy\nof accelerated neon ions died prior to weaning. Offspring prenatally\nirradiated with neon ions generally showed higher incidences of prenatal\ndeath, increased preweaning mortality, markedly delayed accomplishment in\nphysiological markers and reflexes, significantly lower body weight and\nreduced ratios of main organ weight to body weight, and altered behavior\ncompared to those exposed to X-rays at doses of 0.1 to 1.5 Gy. These\nfindings indicate that irradiations with neon ions at 0.1 to 1.5 Gy on day\n15 of gestation caused varied developmental alterations in offspring, and\nefficient dose leading to the detrimental effects seemed to be lower than\nthat of X-rays.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.asr.2006.11.011","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0273-1177","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"445783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"445784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi-Kasai, Kiyomi"}],"nameIdentifiers":[{"nameIdentifier":"445785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojima, Kumie"}],"nameIdentifiers":[{"nameIdentifier":"445786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"445787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"445788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"445789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"445790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moreno, Stephanie.G"}],"nameIdentifiers":[{"nameIdentifier":"445791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Herve, Coffigny"}],"nameIdentifiers":[{"nameIdentifier":"445792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"445793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 恵子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445802","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Prenatal Irradiation with an Accelerated Heavy-Iron Beam on Postnatal Development in Rats: II.. Further Study on Neurophysiologic Alterations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Prenatal Irradiation with an Accelerated Heavy-Iron Beam on Postnatal Development in Rats: II.. Further Study on Neurophysiologic Alterations"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-06-18"},"publish_date":"2007-06-18","publish_status":"0","recid":"44883","relation_version_is_last":true,"title":["Effects of Prenatal Irradiation with an Accelerated Heavy-Iron Beam on Postnatal Development in Rats: II.. Further Study on Neurophysiologic Alterations"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:10:13.470950+00:00"}