{"created":"2023-05-15T14:34:42.397731+00:00","id":44856,"links":{},"metadata":{"_buckets":{"deposit":"16d9f1da-e0d9-4d52-9c3f-92abb7c16e88"},"_deposit":{"created_by":1,"id":"44856","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44856"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044856","sets":["1"]},"author_link":["445463","445460","445458","445461","445462","445459"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"255","bibliographicPageStart":"248","bibliographicVolumeNumber":"238","bibliographic_titles":[{"bibliographic_title":"Radiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: To prospectively assess the usefulness of magnetic resonance (MR) spectroscopy data acquired before the initiation of medical therapy in predicting prognosis in patients with depressive psychosis. MATERIALS AND METHODS: All subjects gave written informed consent to an institutional committee for clinical research-approved study protocol. The clinical course after medication in 52 patients with depressive psychosis (age range, 52-78 years; 21 men, 31 women) was investigated. In all patients, MR spectroscopy was performed with a 1.5-T MR imaging unit before the initiation of medical therapy. Cerebrovascular lesions (CVLs), which appear as high-signal-intensity areas on T2-weighted MR images, were evaluated by using the Fazekas rating scale. Patients were classified into two groups on the basis of the ratio of N-acetylaspartate (NAA) to creatine and phosphocreatine (Cr): Patients in group A had an NAA/Cr ratio greater than 1.91, and patients in group B had an NAA/Cr ratio of 1.91 or less. To assess the response of the patients to medication, standard psychiatric tests--the Verbal Associative Fluency Test (VAFT), the Digit Symbol Test (DST), the Mini-Mental State Examination (MMSE), and the Hamilton Depression Rating Scale (HAM-D)--were administered before and after medical therapy was initiated. Mean test scores before and after medication were compared with paired t testing. P < .05 was considered to indicate a significant difference. RESULTS: There were 25 patients in group A and 27 in group B. In group A, the mean VAFT and DST scores increased and the mean HAM-D score decreased after medication. There was no significant difference in mean MMSE scores before and after medication (P = .945 for group A and P = .934 for group B). In group B, there were no significant differences in any of the psychiatric test scores before and after medication. The high-signal-intensity area score in group B was significantly higher than that in group A (P = .004). CONCLUSION: MR spectroscopy data obtained before the initiation of medical therapy were useful in predicting prognosis in patients with depressive psychosis; this suggests that the combined burden of all CVLs may affect the response to antidepressant medication.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-8419","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kado, Hirotsugu"}],"nameIdentifiers":[{"nameIdentifier":"445458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"445459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Tetsuhito"}],"nameIdentifiers":[{"nameIdentifier":"445460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Ken"}],"nameIdentifiers":[{"nameIdentifier":"445461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanno, Iwao"}],"nameIdentifiers":[{"nameIdentifier":"445462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445463","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-28"},"publish_date":"2007-05-28","publish_status":"0","recid":"44856","relation_version_is_last":true,"title":["Depressive psychosis: clinical usefulness of MR spectroscopy data in predicting prognosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:10:32.417000+00:00"}