@article{oai:repo.qst.go.jp:00044845,
 author = {Iwata, Masaru and Iwakawa, Mayumi and Noda, Shuhei and Oota, Toshie and Yang, Minfu and kimura, Tomo and Shibuya, Hitoshi and Imai, Takashi and 岩田 賢 and 岩川 眞由美 and 野田 秀平 and 太田 敏江 and 菅 智 and 澁谷 均 and 今井 高志},
 issue = {3},
 journal = {International Journal of Radiation Biology},
 month = {Mar},
 note = {PURPOSE: To identify loci concerned with radiosensitivity in a mouse model using single nucleotide polymorphism (SNP) markers. MATERIALS AND METHODS: We subjected 276 second filial generation (F2) mice descended from two inbred mouse strains, radiation-induced apoptosis sensitive C57BL/6JNrs (B6) and radiation-induced apoptosis resistant C3H/HeNrs (C3H), to 2.5 Gy whole-body irradiation. We quantified jejunal crypt apoptosis, performed a genome-wide survey, and identified quantitative trait loci (QTL) associated with radiation sensitivity. We expressed apoptosis levels as an apoptotic score (AS), which was equal to the number of apoptotic bodies divided by the number of crypts. We genotyped the mice for 109 SNP markers. RESULTS: AS values were 97.7+/-32.9 in B6 mice and 49.0+/-24.9 in C3H mice (p < 0.01). Genome-wide analysis revealed 8 markers (2 on chromosome 9, 4 on 15, 1 on 17, and 1 on 18) affecting radiation-induced jejunal apoptosis with log odds (LOD) scores ranging from 2.11+/-3.91. We found a significant locus on chromosome 15, which was previously reported by Weil and colleagues. CONCLUSION: These findings support the view that the radiosensitivity of clinically normal tissue depends on variations in several genes.},
 pages = {181--186},
 title = {Correlation between single nucleotide polymorphisms and jejunal crypt cell apoptosis after whole body irradiation},
 volume = {83},
 year = {2007}
}