{"created":"2023-05-15T14:34:41.525996+00:00","id":44836,"links":{},"metadata":{"_buckets":{"deposit":"d803e50f-2077-474d-a12e-2c4bff8028a1"},"_deposit":{"created_by":1,"id":"44836","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44836"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044836","sets":["1"]},"author_link":["445281","445282","445275","445274","445284","445278","445277","445276","445280","445283","445279"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"413","bibliographicPageStart":"404","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Journal of Cerebral Blood Flow and Metabolism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cerebral vascular mean transit time (MTT), defined as the ratio of cerebral blood volume to cerebral blood flow (CBV/CBF), is a valuable indicator of the cerebral circulation. Positron emission tomography (PET) and dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) are useful for the quantitative determination of MTT in the clinical setting. The aim of this study was to establish a normal value set of MTT as determined by PET and by DSC-MRI and to identify differences between these methods. Seven healthy volunteers were studied with (15)O-PET (H(2)(15)O and C(15)O) and gradient-echo echo-planar DSC-MRI at 1.5 T. In the DSC-MRI study with bolus injection of contrast agent, deconvolution analysis was performed. Comparison of gray-to-white matter ratios showed fairly good agreement between PET and DSC-MRI for all parameters (relative CBV, relative CBF, and relative MTT), confirming the validity of relative measurements with DSC-MRI. However, quantitative MTT measured by DSC-MRI was significantly shorter than that measured by PET in cerebral cortical regions (2.8 to 3.0 secs for DSC-MRI versus 3.9 to 4.3 secs for PET) and the centrum semiovale (3.5 secs for DSC-MRI versus 4.8 secs for PET). These discrepancies may be because of the differences in the intrinsic sensitivity of each imaging modality to vascular components; whereas PET measurement of CBV is equally sensitive to all vascular components, measurement with DSC-MRI originates from the microvasculature in the vicinity of the brain parenchyma. This underlying difference may influence interpretation of MTT determined by PET or by DSC-MRI for patients with cerebrovascular disease.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ibaraki, Masanobu"}],"nameIdentifiers":[{"nameIdentifier":"445274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"445275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Simosegawa, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"445276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishigami, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"445277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"445278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanno, Iwao"}],"nameIdentifiers":[{"nameIdentifier":"445279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"445280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下瀬川 正幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 和弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"445284","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-04-25"},"publish_date":"2007-04-25","publish_status":"0","recid":"44836","relation_version_is_last":true,"title":["Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:10:46.571058+00:00"}