{"created":"2023-05-15T14:34:39.852477+00:00","id":44798,"links":{},"metadata":{"_buckets":{"deposit":"31f70eba-c053-40ac-b07b-403081ab9068"},"_deposit":{"created_by":1,"id":"44798","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44798"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044798","sets":["1"]},"author_link":["444824","444830","444826","444832","444828","444825","444827","444831","444829"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"720","bibliographicPageStart":"713","bibliographicVolumeNumber":"165","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DNA fragmentation was studied in the fragment size range 0.023-5.7 Mbp after irradiation of human fibroblasts with iron-ion beams of four different energies, i.e., 200 MeV/nucleon, 500 MeV/nucleon, 1 GeV/nucleon and 5 GeV/nucleon, with gamma rays used as the reference radiation. The double-strand break (DSB) yield (and thus the RBE for DNA DSB induction) of the four iron-ion beams, which have LETs ranging from 135 to 442 keV/mum, does not vary greatly as a function of LET. As a consequence, the variation of the cross section for DSB induction mainly reflects the variation in LET. However, when the fragmentation spectra were analyzed with a simple theoretical tool that we recently introduced, the results showed that spatially correlated DSBs, which are absent after gamma irradiation, increased markedly with LET for the iron-ion beams. This occurred because iron ions produce DNA fragments smaller than 0.75 Mbp with a higher probability than gamma rays (a probability that increases with LET). These sizes include those expected from fragmentation of the chromatin loops with Mbp dimensions. This result does not exclude a correlation at distances smaller than the lower size analyzed here, i.e. 23 kbp. Moreover, the DSB correlation is dependent on dose, decreasing when dose increases; this can be explained with the argument that at increasing dose there is an increasing fraction of fragments produced by DSBs caused by separate, uncorrelated tracks.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Belli, Mauro"}],"nameIdentifiers":[{"nameIdentifier":"444824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Campa, A"}],"nameIdentifiers":[{"nameIdentifier":"444825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dini, Valentina"}],"nameIdentifiers":[{"nameIdentifier":"444826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Esposito, G"}],"nameIdentifiers":[{"nameIdentifier":"444827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"444828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Simone, Giustina"}],"nameIdentifiers":[{"nameIdentifier":"444829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sorrentino, Eugenio"}],"nameIdentifiers":[{"nameIdentifier":"444830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Antonella, Tabocchini Maria"}],"nameIdentifiers":[{"nameIdentifier":"444831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444832","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DNA fragmentation induced in human fibroblasts by accelerated 56fe ions of differing energies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA fragmentation induced in human fibroblasts by accelerated 56fe ions of differing energies"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-02-27"},"publish_date":"2007-02-27","publish_status":"0","recid":"44798","relation_version_is_last":true,"title":["DNA fragmentation induced in human fibroblasts by accelerated 56fe ions of differing energies"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:11:13.609449+00:00"}