@article{oai:repo.qst.go.jp:00044768,
 author = {Takabatake, Takashi and Katsuyoshi, Fujikawa and Tanaka, Satoshi and Hirouchi, Tokuhisa and Nakamura, Shingo and Tanaka, Igunasya and Ichinohe, Kazuaki and Saitou, Mikio and Kakinuma, Shizuko and Nishimura, Mayumi and Shimada, Yoshiya and Oghiso, Yoichi and Tanaka, Kimio and et.al and 藤川 勝義 and 田中 聡 and 中村 慎吾 and 一戸 一晃 and 斎藤 幹男 and 柿沼 志津子 and 西村 まゆみ and 島田 義也 and 田中 公夫},
 issue = {1},
 journal = {Radiation Research},
 month = {Jul},
 note = {We previously reported that mice chronically irradiated with low-dose-rate gamma rays had significantly shorter mean life spans than nonirradiated controls. This life shortening appeared to be due primarily to earlier death due to malignant lymphomas in the irradiated groups (Tanaka et al., Radiat. Res. 160, 376-379, 2003). To elucidate the molecular pathogenesis of murine lymphomas after low-dose-rate irradiation, chromosomal aberrations in 82 malignant lymphomas from mice irradiated at a dose rate of 21 mGy/day and from nonirradiated mice were compared precisely by microarray-based comparative genomic hybridization (array-CGH) analysis. The array carried 667 BAC clones densely selected for the genomic regions not only of lymphoma-related loci but also of surface antigen receptors, enabling immunogenotyping. Frequent detection of the apparent loss of the Igh region on chromosome 12 suggested that most lymphomas in both groups were of B-cell origin. Array-CGH profiles showed a frequent gain of whole chromosome 15 in lymphomas predominantly from the irradiated group. The profiles also demonstrated copy-number imbalances of partial chromosomal regions. Partial gains on chromosomes 12, 14 and X were found in tumors from nonirradiated mice, whereas losses on chromosomes 4 and 14 were significantly associated with the irradiated group. These findings suggest that lymphomagenesis under the effects of continuous low-dose-rate irradiation is accelerated by a mechanism different from spontaneous lymphomagenesis that is characterized by the unique spectrum of chromosomal aberrations.},
 pages = {61--72},
 title = {Array-CGH Analyses of Murine Malignant Lymphomas: Genomic Clues to Understanding the Effects of Chronic Exposure to Low-Dose-Rate Gamma Rays on Lymphomagenesis},
 volume = {166},
 year = {2006}
}