{"created":"2023-05-15T14:34:36.863286+00:00","id":44731,"links":{},"metadata":{"_buckets":{"deposit":"67ef18b0-a819-47b7-bf15-22c492a41978"},"_deposit":{"created_by":1,"id":"44731","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44731"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044731","sets":["1"]},"author_link":["444096","444094","444092","444090","444100","444091","444099","444093","444098","444097","444095"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"513","bibliographicPageStart":"509","bibliographicVolumeNumber":"164","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Caffeine sensitizes cells to ionizing radiation and this effect is believed to be associated with the disruption of DNA damage-responsive cell cycle checkpoints, which is controlled by ATM. Recent studies suggest that misrejoining of dsbs is one of the underlying mechanisms of A-T cell hyper radiosensitivity. In this study, we investigated the effects of caffeine and radiation on non-growing G-0 phase normal human fibroblast cells by determining cell survival and scoring aberrations in calyculin-A induced G2 chromosomes. Results from the cell survival study indicate that after X-ray exposure G0 cells were sensitized by 24-h treatment with caffeine. Analysis of chromosome aberrations using FISH (fluorescence in situ hybridization) revealed a high frequency of aberrant cells and color-junctions in the caffeine treated cells. Since the majority of DNA repair in non-growing G-0 cells is believed to undergo non-homologous end joining (NHEJ), caffeine may influence the fidelity of NHEJ pathway in irradiated G-0 phase cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawata, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"444090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"444091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saitou, Masayoshi"}],"nameIdentifiers":[{"nameIdentifier":"444092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uno, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"444093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"444094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"444095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川田 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊東 久夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"斉藤 正好","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇野 隆","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"444100","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Caffeine sensitizes nondividing human fibroblasts to X rays by inducing a high frequency of misrepair","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Caffeine sensitizes nondividing human fibroblasts to X rays by inducing a high frequency of misrepair"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-11-30"},"publish_date":"2006-11-30","publish_status":"0","recid":"44731","relation_version_is_last":true,"title":["Caffeine sensitizes nondividing human fibroblasts to X rays by inducing a high frequency of misrepair"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:12:01.011882+00:00"}