@article{oai:repo.qst.go.jp:00044731,
 author = {Kawata, Tetsuya and Ito, Hisao and Saitou, Masayoshi and Uno, Takashi and Okayasu, Ryuichi and et.al and 川田 哲也 and 伊東 久夫 and 斉藤 正好 and 宇野 隆 and 岡安 隆一},
 issue = {4},
 journal = {Radiation Research},
 month = {},
 note = {Caffeine sensitizes cells to ionizing radiation and this effect is believed to be associated with the disruption of DNA damage-responsive cell cycle checkpoints, which is controlled by ATM. Recent studies suggest that misrejoining of dsbs is one of the underlying mechanisms of A-T cell hyper radiosensitivity. In this study, we investigated the effects of caffeine and radiation on non-growing G-0 phase normal human fibroblast cells by determining cell survival and scoring aberrations in calyculin-A induced G2 chromosomes. Results from the cell survival study indicate that after X-ray exposure G0 cells were sensitized by 24-h treatment with caffeine. Analysis of chromosome aberrations using FISH (fluorescence in situ hybridization) revealed a high frequency of aberrant cells and color-junctions in the caffeine treated cells. Since the majority of DNA repair in non-growing G-0 cells is believed to undergo non-homologous end joining (NHEJ), caffeine may influence the fidelity of NHEJ pathway in irradiated G-0 phase cells.},
 pages = {509--513},
 title = {Caffeine sensitizes nondividing human fibroblasts to X rays by inducing a high frequency of misrepair},
 volume = {164},
 year = {2005}
}