@article{oai:repo.qst.go.jp:00044610,
 author = {Kato, Shingo and Ohno, Tatsuya and Tsujii, Hirohiko and Nakano, Takashi and Mizoe, Junetsu and Kamada, Tadashi and Miyamoto, Tadaaki and Tsuji, Hiroshi and Katou, Hirotoshi and Yamada, Shigeru and Kandatsu, Susumu and Yoshikawa, Kyosan and Ezawa, Hidefumi and Suzuki, Michiya and 加藤 眞吾 and 大野 達也 and 辻井 博彦 and 中野 隆史 and 溝江 純悦 and 鎌田 正 and 宮本 忠昭 and 辻 比呂志 and 加藤 博敏 and 山田 滋 and 神立 進 and 吉川 京燦 and 江澤 英史 and 鈴木 通也},
 issue = {2},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Jun},
 note = {Purpose: To evaluate the toxicity and efficacy of carbon ion radiotherapy (CIRT) for locally advanced cervical cancer by two phase I/II clinical trials.
Methods and Materials: Between June 1995 and January 2000, 44 patients were treated with CIRT. Thirty patients had stage IIIB disease and 14 patients had stage IVA disease. Median tumor size was 6.5 cm (4.2-11.0 cm). The treatment consisted of 16 fractions of whole pelvic irradiation and 8 fractions of local boost. In the first study, the total dose ranged from 52.8 to 72.0 gray equivalent (GyE) (2.2 to 3.0 GyE/fraction). In the second study, the whole pelvic dose was fixed at 44.8 GyE, and an additional 24.0 or 28.0 GyE was given to the cervical tumor (total dose: 68.8 or 72.8 GyE).
Results: No patient developed severe acute toxicity. In contrast, 8 patients developed major late gastrointestinal complications. The doses resulting in major complications were over 60 GyE. All patients with major complications were surgically salvaged. The 5-year local control rates for patients in the first and second studies were 45% and 79%, respectively. When treated with 62.4 GyE or more, the local control was favorable even for the patients with stage IVA disease (69%) or for those with tumors > 6.0 cm (64%).
Conclusions:  In CIRT for advanced cervical cancer, the dose to the intestines should be limited to less than 60 GyE to avoid major complications. Although the number of patients was small, the results supported the continued investigation to confirm therapeutic efficacy.},
 pages = {388--397},
 title = {Dose Escalation study of Carbon Ion Radiotherapy  for Locally Advanced Carcinoma of the Uterine Cervix.},
 volume = {65},
 year = {2006}
}