{"created":"2023-05-15T14:34:27.237500+00:00","id":44514,"links":{},"metadata":{"_buckets":{"deposit":"fd2e12b1-f3c7-4e1d-b0b0-21f85f188f3a"},"_deposit":{"created_by":1,"id":"44514","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44514"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044514","sets":["1"]},"author_link":["442324","442327","442325","442322","442326","442323"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"928","bibliographicPageStart":"919","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Biological Psychiatry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite numerous studies on extrastriatal regions involved in schizophrenia, studies on the functional implications of dopamine (DA)\nD2 receptors in the extrastriatal regions, including the cortex and thalamus, are limited. We review postmortem and in vivo human\nimaging studies as well as animal studies, focusing on the function of extrastriatal DA D2 receptors and their role in the\npathophysiology of schizophrenia. Based on recent findings, cortical DA D2 receptors may interact with the gamma-aminobutyric acid\nsystem to modulate DA transmission, and thalamic DA D2 receptors are likely to participate in sensory gating function into the\nprefrontal cortex. We have found decreased DA D2 receptors in the anterior cingulate cortex and thalamic subregions of patients with\nschizophrenia. These observations may suggest that alterations of extrastriatal DA D2 receptors are involved in dysregulation of DA\ntransmission and sensory signals from the thalamus to the cortex. Excessive excitatory signals from the thalamus might flow into the\ncortical neurotransmission system, aggravating dysregulation of DA transmission in both the striatal and extrastriatal regions in\nschizophrenia. These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues\nregarding the pathogenesis and of possible treatments for schizophrenia.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-3223","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"442322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"442323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"442324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"442325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"442326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"442327","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The role of extrastriatal dopamine D2 receptors in schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of extrastriatal dopamine D2 receptors in schizophrenia"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-08-01"},"publish_date":"2006-08-01","publish_status":"0","recid":"44514","relation_version_is_last":true,"title":["The role of extrastriatal dopamine D2 receptors in schizophrenia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:14:34.470425+00:00"}