@article{oai:repo.qst.go.jp:00044514,
 author = {Takahashi, Hidehiko and Higuchi, Makoto and Suhara, Tetsuya and 高橋 英彦 and 樋口 真人 and 須原 哲也},
 issue = {10},
 journal = {Biological Psychiatry},
 month = {May},
 note = {Despite numerous studies on extrastriatal regions involved in schizophrenia, studies on the functional implications of dopamine (DA)
D2 receptors in the extrastriatal regions, including the cortex and thalamus, are limited. We review postmortem and in vivo human
imaging studies as well as animal studies, focusing on the function of extrastriatal DA D2 receptors and their role in the
pathophysiology of schizophrenia. Based on recent findings, cortical DA D2 receptors may interact with the gamma-aminobutyric acid
system to modulate DA transmission, and thalamic DA D2 receptors are likely to participate in sensory gating function into the
prefrontal cortex. We have found decreased DA D2 receptors in the anterior cingulate cortex and thalamic subregions of patients with
schizophrenia. These observations may suggest that alterations of extrastriatal DA D2 receptors are involved in dysregulation of DA
transmission and sensory signals from the thalamus to the cortex. Excessive excitatory signals from the thalamus might flow into the
cortical neurotransmission system, aggravating dysregulation of DA transmission in both the striatal and extrastriatal regions in
schizophrenia. These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues
regarding the pathogenesis and of possible treatments for schizophrenia.},
 pages = {919--928},
 title = {The role of extrastriatal dopamine D2 receptors in schizophrenia},
 volume = {59},
 year = {2006}
}