{"created":"2023-05-15T14:34:24.227632+00:00","id":44447,"links":{},"metadata":{"_buckets":{"deposit":"41d468d6-341b-4524-b4a7-b70043ab3e5e"},"_deposit":{"created_by":1,"id":"44447","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44447"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044447","sets":["1"]},"author_link":["441692","441693","441694","441691","441695"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"808","bibliographicPageStart":"801","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For mapping brain acetylcholinesterase (AchE) in vivo. seven radioactive acetylcholine analogs, N-[14C]methylpiperidyl-3- and 4-acetates, propionates, isobutyrates, and 3-butyrate were newly synthesized and evaluated in mice. The esters readily entered the brain and were hydrolyzed into the hydrophilic metabolite, which was trapped. In brain homogenates, the esters showed a wide range of enzymatic reactivity (about 40-fold), and high specificity for AchE (more than 82%) except the butrate. Intra-brain distribution of the esters reflected a pattern of AchE activity.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0969-8051","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"441691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"441692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"441693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"441695","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-07"},"publish_date":"2006-07-07","publish_status":"0","recid":"44447","relation_version_is_last":true,"title":["Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:15:21.365045+00:00"}