@article{oai:repo.qst.go.jp:00044447,
 author = {Irie, Toshiaki and Fukushi, Kiyoshi and et.al and 入江 俊章 and 福士 清},
 issue = {6},
 journal = {Nuclear Medicine and Biology},
 month = {},
 note = {For mapping brain acetylcholinesterase (AchE) in vivo. seven radioactive acetylcholine analogs, N-[14C]methylpiperidyl-3- and 4-acetates, propionates, isobutyrates, and 3-butyrate were newly synthesized and evaluated in mice. The esters readily entered the brain and were hydrolyzed into the hydrophilic metabolite, which was trapped. In brain homogenates, the esters showed a wide range of enzymatic reactivity (about 40-fold), and high specificity for AchE (more than 82%) except the butrate. Intra-brain distribution of the esters reflected a pattern of AchE activity.},
 pages = {801--808},
 title = {Design and Evaluation of Radioactive Acetylcholine Analogs for Mapping Brain Acetylcholinesterase (AchE) In Vivo},
 volume = {21},
 year = {1994}
}