@article{oai:repo.qst.go.jp:00044405,
 author = {Shinotoh, Hitoshi and Aotsuka, Akiyo and Fukushi, Kiyoshi and Nagatsuka, Shin-ichiro and Tanaka, Noriko and Ota, Tsuneyoshi and Tanada, Shuji and Irie, Toshiaki and 篠遠 仁 and 青墳 章代 and 福士 清 and 長塚 伸一郎 and 田中 典子 and 黄田 常嘉 and 棚田 修二 and 入江 俊章},
 journal = {Neurology},
 month = {},
 note = {Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5mg/d in two patients, 3mg/d in one patient) using PET and N-[11C] methylpiperidin-4-yl acetae. Donepezil reduced K3 values,showed some degree of symptomatic improvement, and it was concluded that this improvement was likely caused by improved cholinergic activity by inhibition of AChE in the brain.},
 pages = {408--410},
 title = {Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET},
 volume = {56},
 year = {2001}
}