@article{oai:repo.qst.go.jp:00044401, author = {Obata, Takayuki and Ikehira, Hiroo and Koga, Masahisa and Yoshida, Katsuya and Tateno, Yukio and et.al and 小畠 隆行 and 池平 博夫 and 古賀 雅久 and 吉田 勝哉 and 舘野 之男}, issue = {4}, journal = {Magnetic Resonance in Medicine}, month = {Apr}, note = {We used deuterium magnetic resonance imaging (2H MRI) to visualize water movement in the rabbit eye. Dynamic 2H MRI was obtained every 3.5 min at 2 tesla by FLASH pulse sequence (TR, 300 ms; TE, 10 ms; alpha = 90 degrees) with a slice thickness of 10 mm using a surface coil (4 cm in diameter). After topical administration (0.2 ml D2O), only the aqueous chamber was imaged, and the signals decreased mono-exponentially. The flow rate was 0.113/min, in agreement with that already reported. After intravenous administration of deuterated saline (3 ml/kg), the aqueous chamber became visible first during imaging, then by the vitreous body. The signals around the lens were only faintly detected. Thus, deuterium MRI was determined to be useful for visualizing water movement in the eye.}, pages = {569--572}, title = {Deuterium magnetic resonance imaging of rabbit eye in vivo.}, volume = {33}, year = {1995} }