@article{oai:repo.qst.go.jp:00044397,
 author = {Sato, Koichi and Fukushi, Kiyoshi and Shinoto, Hitoshi and Nagatsuka, Shinnichiro and Tanaka, Noriko and Aotsuka, Akiyo and Ota, Tsuneyoshi and Shiraishi, Tetsuya and Tanada, Shuji and Iyo, Masaomi and Irie, Toshiaki and 佐藤 康一 and 福士 清 and 篠遠 仁 and 長塚 伸一郎 and 田中 典子 and 青墳 章代 and 黄田 常嘉 and 白石 哲也 and 棚田 修二 and 入江 俊章},
 issue = {6},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {},
 note = {The applicability of two reference tissue-based analyses without arterial blood sampling for the measurement of brain regional acetylcholinesterase (AChE) activity using N-[11C]methylpiperidin-4-yl propionate ([11C]MP4P) was evaluated in 12 healthy subjects. One was a linear least squares analysis derived from Blomqvist's equation, and the other was the analysis of the ratio of target-tissue radioactivity relative to reference-tissue radioactivity proposed by Hertholz and coworkers. The standard compartment analysis using arterial input function provided reliable quantification of k3 (an index of AChE activity) estimates in regions with low (neocortex and hippocampus), moderate (thalamus), and high (cerebellum) AChE activity with a coefficient of variation (COV) of 12% to 19%. However, the precise k3 value in the striatum, where AChE activity is the highest, was not obtained.  The striatum was used as a reference because its time-radioactivity cure was proportional to the time integral of the arterial input function. Reliable k3 estimates were also obtained in regions with low-to-moderate AChE activity with a COV of less than 21% by striatal reference analyses, though not obtained in the cerebellum. Shape analysis, the previous method of direct k3 estimation from the shape of time-radioactivity data, gave k3 estimates in the cortex and thalamus with a somewhat larger COV. In comparison with the standard analysis, a moderate overstimation of k3 by 9% to 18% in the linear analysis and a moderate understimation by 2% to 13% in the Herholz method were observed, which were appropriately explained by the results of computer simulation. In conclusion, simplified kinetic analyses are practical and useful for the routine analysis of clinical [11C]MP4P studies and are nearly as effective as the standard analysis for detecting regions with abnormal AChE activity.},
 pages = {600--611},
 title = {Evaluation of Simplified Kinetic Analyses for Measurement of Brain Acetylcholinesterase Activity Using N-[11C]Methylpiperidin-4-yl Propionate and Positron Emission Tomography},
 volume = {24},
 year = {2004}
}