@article{oai:repo.qst.go.jp:00044389, author = {Kobayashi, Kaoru and Hosoi, Rie and Momosaki, Sotaro and Koike, Sachiko and Ando, Koichi and Nishimura, Tsunehiko and Inoue, Osamu and 細井 理恵 and 小池 幸子 and 安藤 興一 and 井上 修}, journal = {Annals of Nuclear Medicine}, month = {}, note = {fluorodeoxyglucose(18F-FDG) in tumor tissue was examined in mice transplanted with FNSa firbrosarcoma. The uptake indexes of 18F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatment with 3 mg/kg of roliprom (heart:13%, skeletal muscle:14%, brain :13%), but fibrosarcoma tissue showed only a 50% reduction in the uptake of 18F-FDG. The tumor/muscle ratio of radioactivity 30 min after 18F-FDG injection was consequently enhanced from 1.9 to 6.5 by roliprom. This indicates the possible use of roliprom to enhance the sensitivity of tumor detection, as well as characterization of tumors in 18F-FDG PET.}, pages = {507--510}, title = {Enhancement of the relative uptake of 18F-FDG in mouse fibrosarcoma by rolipram}, volume = {16}, year = {2002} }