@article{oai:repo.qst.go.jp:00044362, author = {Fujimori, Akira and Hashimoto, Hiroshi and Araki, Ryoko and Saito, Toshiyuki and Sato, Shinji and Kasama, Yasuji and Tsutsumi, Yoko and Mori, Masahiko and Fukumura, Ryuutarou and Ohhata, Tatsuya and Tatsumi, Kouichi and Abe, Masumi and 藤森 亮 and 荒木 良子 and 齋藤 俊行 and 笠間 康次 and 森 雅彦 and 福村 龍太郎 and 巽 紘一 and 安倍 真澄}, journal = {Radiation Research}, month = {Mar}, note = {The catalytic subunit of DNA-dependent protein kinase plays critical roles in nonhomologous end joining in repair of DNA double-strand breaks and V(D)J recombination. In addition to the SCID phenotype, it has been suggested that the molecule contributes to the polymorphic variations in radiosensitivity and susceptibility to cancer in mouse strains. Here we show the nucleotide sequence of approximately 193-kbp and 84-kbp genomic regions encoding the entire Prkdc gene (also known as DNA-PKcs) in the mouse and chicken, respectively. A large retroposon was found in intron 51 in the mouse but not in the human or chicken. Comparative analyses of the genome strongly suggested that the region contains only two genes for Prkdc and Mcm4; however, several conserved sequences and cis elements were also predicted.}, pages = {298--305}, title = {Sequence analysis of 193.4 and 83.9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc (DNA-PKcs) gene}, volume = {157}, year = {2002} }