@article{oai:repo.qst.go.jp:00044306, author = {Takei, Makoto and Kida, Takayo and Suzuki, Kazutoshi and 鈴木 和年}, journal = {Applied Radiation and Isotopes}, month = {}, note = {For sensitive analysis of the radioactive-metabolite in human PET, a radio-HPLC system coupled to a newly designed positron detector was constructed. The detector had the advantages of low noise level(1.7+/-1.0cpm)and high sensitivity(32+/-1%)due to coincidence counting and large BGO crystals. Furthermore, the detector was easy to move,since a pair of the BGO housings coupled to photomultipliers was effectively arranged in parallel and a HPLC cell with different volume could be inserted between the BGO housing. This radio-HPLC system was useful for analyzing samples with low radioactivity. It was applied to the measurement of [11C]FLB457in plasma,having high affinity and high selectivity with dopamine D2 receptors. Extremely low radioactivity of [11C]FLB457(2500dpm)could be analzed by using the radio-HPLC system. The performance of this detector was compared with those of commercially available systems that had been used as sensitive detectors for HPLC. (C)2001 Elsevier Science Ltd. All rights reserved.}, pages = {229--234}, title = {Sensitive measurement of positron emitters eluted from HPLC}, volume = {55}, year = {2001} }