{"created":"2023-05-15T14:34:11.078599+00:00","id":44242,"links":{},"metadata":{"_buckets":{"deposit":"46b0c03d-cdca-482b-ba50-727083971941"},"_deposit":{"created_by":1,"id":"44242","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44242"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044242","sets":["1"]},"author_link":["439550","439548","439551","439552","439547","439556","439553","439554","439555","439557","439546","439549"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"65","bibliographicPageStart":"59","bibliographicVolumeNumber":"1762","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta. Molecular Basis of Disease"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Possible association between the C282Y and H63D mutations in the HFE gene and estrogen-dependent cancer risk was assessed. Genotyping was performed using PCR amplification followed by digestion of products with specific restrictases. In a population of 260 healthy women (permanent residents of the southwest European Russia), mutant allele frequencies at the C282Y and H63D sites were evaluated as 3.3 and 16.3%, respectively. In patients with breast, ovarian, or endometrial cancer, C282Y frequencies were also low (1.0, 1.3, and 3.8%, respectively), and no cancer risk associated with the C282Y mutation was found. Odds ratios for breast cancer risk associated with the H63D mutation increased significantly with age: 0.5 in women below 48 years old, 1.0 in a range of 48-57 years, and 4.4 in older women (ptrend=0.002). The latter value was statistically significant (95% CI, 1.4-14.1), indicating that women bearing the H63D mutation may be at an increased breast cancer risk at an age above 57 years. Preliminary results obtained in patients with two other estrogen-dependent malignancies revealed the same tendency to OR increase with age in ovarian cancer patients (ptrend=0.008), but no age-related OR differences in endometrial cancer patients.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0925-4439","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"V., Kondrashova Tatiana"}],"nameIdentifiers":[{"nameIdentifier":"439546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Neriishi, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"439547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ban, Sadayuki"}],"nameIdentifiers":[{"nameIdentifier":"439548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"I., Ivanova Tatiana"}],"nameIdentifiers":[{"nameIdentifier":"439549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"I., Krikunova Lyudmila"}],"nameIdentifiers":[{"nameIdentifier":"439550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"I., Shentereva Nataliya"}],"nameIdentifiers":[{"nameIdentifier":"439551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A., Smirnova Iya"}],"nameIdentifiers":[{"nameIdentifier":"439552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A., Zharikova Irina"}],"nameIdentifiers":[{"nameIdentifier":"439553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"V., Konova Marina"}],"nameIdentifiers":[{"nameIdentifier":"439554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taira, Senjun"}],"nameIdentifiers":[{"nameIdentifier":"439555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"F., Tsyb Anatoly"}],"nameIdentifiers":[{"nameIdentifier":"439556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伴 貞幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"439557","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-13"},"publish_date":"2006-06-13","publish_status":"0","recid":"44242","relation_version_is_last":true,"title":["Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:17:46.525042+00:00"}