@article{oai:repo.qst.go.jp:00044019,
 author = {Sassa, Takeshi and Suhara, Tetsuya and Ikehira, Hiroo and Obata, Takayuki and Girard, F and Tanada, Shuji and Okubo, Yoshiro and 佐々 毅 and 須原 哲也 and 池平 博夫 and 小畠 隆行 and 棚田 修二 and 大久保 善朗},
 issue = {6},
 journal = {Psychiatry and Clinical Neurosciences},
 month = {Dec},
 note = {Haloperidol decanoate is widely used in the maintenance treatment of schizophrenia and other psychotic disorders, but knowledge concerning its pharmacokinetics at the injected region is very limited. Because the chemical structure of haloperidol contains fluorine, in vivo 19F-magnetic resonance (MR) spectroscopy (repetition time (TR) = 1 s) and chemical shift imaging (CSI; TR = 1 s, pixel size = 15 x 15 mm) were performed in schizophrenic patients who were treated with haloperidol decanoate (three men and one woman) to measure its diachronic change at the injection point and visualize its local distribution after intramuscular injection. 19F signals (T1 time = 365 ms) were obtained at the haloperidol decanoate-injected region. The decrease rate of the signal-to-noise ratio (SNR) by 19F-MR spectroscopy seemed large in comparison with that of the plasma haloperidol concentration. The distribution was clearly visualized by 19F-CSI for a few days after the injection, but after 1 week could no longer be seen. Although the slow-release characteristics of depot neuroleptics have been explained by the slow diffusion of esterified neuroleptics from the oil vehicle, this result may suggest that there are other mechanisms involved in maintaining the plasma haloperidol concentration. In vivo 19F-MR spectroscopy and CSI are potentially applicable for the pharmacokinetic analysis of haloperidol and other drugs containing fluorine in their structure.},
 pages = {637--642},
 title = {19F-magnetic resonance spectroscopy and chemical shift imaging for schizophrenic patients using haloperidol decanoate},
 volume = {56},
 year = {2002}
}