{"created":"2023-05-15T14:33:54.755473+00:00","id":43991,"links":{},"metadata":{"_buckets":{"deposit":"5acb7aad-813f-4879-a319-acd05d201733"},"_deposit":{"created_by":1,"id":"43991","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43991"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043991","sets":["1"]},"author_link":["437269","437268","437267"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"318","bibliographicPageStart":"311","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Carcinogenesis"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia(AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0143-3334","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"437267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"437268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"437269","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-02-20"},"publish_date":"2006-02-20","publish_status":"0","recid":"43991","relation_version_is_last":true,"title":["Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:20:41.716257+00:00"}