@article{oai:repo.qst.go.jp:00043952,
 author = {Koike, Manabu and Ninomiya, Yasuharu and Koike, Aki and 小池 学 and 二宮 康晴 and 小池 亜紀},
 journal = {Journal of Radiation Research},
 month = {},
 note = {The epidermis is a physiological barrier that protects an organism against pathogens and chemical or physical damage. The degree of skin injuries caused by radiation influences the subsequent survival from and prognosis of such injuries. Recently, we have identified, using microarray technology, gene regulated by high-dose radiation exposure in normal human epidermal keratinocytes. Our results suggest the possible role of ATF3 in the apoptosis pathway in radiation injuries caused by high-dose radiation exposure in human skin. In the present study, we characterized ATF3 induction after X-ray irradiation in normal human skin cells. Our results showed that the induction of ATF3 mRNA is rapid, transient, and at least in part mediated through a transcriptional mechanism after X-irradiation of normal human keratinocytes. In addition, ATF3 was induced and accumulated in the nuclei of keratinocytes upon treatment with an apoptosis inducer, anisomycin. Our results also suggested that the induction mechanism of ATF3 mRNA by X-irradiation may be different not only between epidermal keratinocytes and dermal fibroblasts, but also between dermal fibloblasts and lung fibroblasts.},
 pages = {379--385},
 title = {Characterization of ATF3 Induction after Ionizing Radiation in Human Skin Cells},
 volume = {46},
 year = {2005}
}