{"created":"2023-05-15T14:33:52.897715+00:00","id":43951,"links":{},"metadata":{"_buckets":{"deposit":"339f19f4-0529-47ef-8fcc-9119290c87b9"},"_deposit":{"created_by":1,"id":"43951","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43951"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043951","sets":["1"]},"author_link":["436912","436915","436914","436911","436909","436913","436910"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"468","bibliographicPageStart":"461","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The skin is an eternal organ that is most frequently exposed to radiation. High-dose radiation initiates and promotes acute radiation injury. Thus, it is important to investigate the influence of high-dose radiation exposure on the skin at the molecular level. The post-translational modification of p53 plays a central role in radiation responses, including apoptosis and cell growth arrest. Although it is well known that ataxia telangiectasia mutated (ATM) kinase and DNA-dependent protein kinase (DNA-PK) can phosphorylate Ser15/Ser18 of p53 in vitro, the post-translational modification pattern and the modifier of p53 in the skin after exposure to high-dose X-rays are not yet well understood. Here we show that the phosphorylation of p53 on Ser15/Ser18, as well as the phosphorylation of histone H2AX on Ser139, was detected in the keratinocytes of the mouse skin and human skin models after high-dose X-ray irradiation. Following high-dose X-ray irradiation, both proteins were also phosphorylated in the skin keratinocytes of both ATM gene knockout mice and DNA-PK-deficient SCID mice.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koike, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"436909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugasawa, Jun"}],"nameIdentifiers":[{"nameIdentifier":"436910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Aki"}],"nameIdentifiers":[{"nameIdentifier":"436911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohno, Yohko"}],"nameIdentifiers":[{"nameIdentifier":"436912","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 学","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436913","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅澤 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436914","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 亜紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436915","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-01-04"},"publish_date":"2006-01-04","publish_status":"0","recid":"43951","relation_version_is_last":true,"title":["p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:21:09.656988+00:00"}