@article{oai:repo.qst.go.jp:00043951,
 author = {Koike, Manabu and Sugasawa, Jun and Koike, Aki and Kohno, Yohko and 小池 学 and 菅澤 純 and 小池 亜紀},
 journal = {Journal of Radiation Research},
 month = {},
 note = {The skin is an eternal organ that is most frequently exposed to radiation. High-dose radiation initiates and promotes acute radiation injury. Thus, it is important to investigate the influence of high-dose radiation exposure on the skin at the molecular level. The post-translational modification of p53 plays a central role in radiation responses, including apoptosis and cell growth arrest. Although it is well known that ataxia telangiectasia mutated (ATM) kinase and DNA-dependent protein kinase (DNA-PK) can phosphorylate Ser15/Ser18 of p53 in vitro, the post-translational modification pattern and the modifier of p53 in the skin after exposure to high-dose X-rays are not yet well understood. Here we show that the phosphorylation of p53 on Ser15/Ser18, as well as the phosphorylation of histone H2AX on Ser139, was detected in the keratinocytes of the mouse skin and human skin models after high-dose X-ray irradiation. Following high-dose X-ray irradiation, both proteins were also phosphorylated in the skin keratinocytes of both ATM gene knockout mice and DNA-PK-deficient SCID mice.},
 pages = {461--468},
 title = {p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure},
 volume = {46},
 year = {2005}
}