@article{oai:repo.qst.go.jp:00043921, author = {Ishii, Hideshi and Igarashi, Tadahiko and Saito, Toshiyuki and Nakano, Takashi and Mori, Masahiko and Ohyama, Harumi and Miyamoto, Tadaaki and Saito, Yasushi and Oh, Hakumei and 齋藤 俊行 and 仲野 高志 and 森 雅彦 and 大山 ハルミ and 宮本 忠昭}, journal = {American Journal of Hematology}, month = {May}, note = {Inactivation of the retinoblastoma susceptibility (Rb) gene has been observed in various cancers. Nevertheless, in several cancer cases, including non-Hodgkin's lymphoma, previous investigations showed that the Rb gene product (pRb) was abundantly expressed with varying degree. Here we report the THS-SP1.1 cell line isolated from non-Hodgkin's lymphoma. The THS-SP1.1 cells abundantly expressed pRb and showed resistance against radiation-induced apoptosis. Culture with the antisense phosphorothioate oligonucleotide complementary to the Rb gene augmented the apoptosis of THS-SP1.1 cells after radiation, whereas the control oligonucleotides did not. These data showed that pRb abundantly expressed in the lymphoma cells inhibited radiation-induced apoptosis.}, pages = {46--48}, title = {Retinoblastoma protein expressed in human non-Hodgkin's lymphoma cells generates resistance against radiation-induced apoptosis.}, volume = {55}, year = {1997} }