{"created":"2023-05-15T14:33:51.351018+00:00","id":43918,"links":{},"metadata":{"_buckets":{"deposit":"79f2c4bc-e397-46d2-a9a8-32bf01c88675"},"_deposit":{"created_by":1,"id":"43918","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43918"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043918","sets":["1"]},"author_link":["436607","436610","436604","436605","436606","436602","436611","436609","436608","436603"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1056","bibliographicPageStart":"1049","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"International Immunology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SDF-1 is a member of the CXC chemokines. In contrast to other chemokines that are induced by inflammation, SDF-1 is constitutively produced by stromal cells. In order to investigate the physiological roles of SDF-1, we constructed a fusion protein, SDF-1-Cgamma1, composed from murine SDF-1alpha and the constant region of human IgG. SDF-1-Cgamma1 stained EL-4 T lymphoma cells and the staining was blocked by rhSDF-1beta. The expression levels of SDF-1R altered along with the T cell maturation. Most c-kit+ hematopoietic precursors in fetal liver in gestational day (GD) 14.5 embryo were SDF-1R-, while c-kit+ double-negative (DN) thymocytes in the embryo were positive for SDF-1R. The receptor expression increased along with T cell maturation up to double-positive (DP) cell stage. Interestingly, SDF-1R expression was down-modulated after positive selection; CD69+CD3hi DP and CD3hi single-positive thymocytes were SDF-1R-/lo. Northern blot analysis demonstrated that SDF-1 and CXCR4 mRNAs were abundantly expressed in the thymuses of embryo and adult mice. These results demonstrate that SDF-1R expression is involved in T cell development in the thymus, particularly in positive selection.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0953-8178","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Gen"}],"nameIdentifiers":[{"nameIdentifier":"436602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakagawa, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"436603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"436604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mita, Kazuei"}],"nameIdentifiers":[{"nameIdentifier":"436605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shirasawa, Takuji"}],"nameIdentifiers":[{"nameIdentifier":"436606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"436607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川 憲一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 俊行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三田 和英","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436611","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loss of SDF-1 receptor expression during positive selection in the thymus.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of SDF-1 receptor expression during positive selection in the thymus."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-12-16"},"publish_date":"2005-12-16","publish_status":"0","recid":"43918","relation_version_is_last":true,"title":["Loss of SDF-1 receptor expression during positive selection in the thymus."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:21:32.746850+00:00"}