{"created":"2023-05-15T14:33:51.213011+00:00","id":43915,"links":{},"metadata":{"_buckets":{"deposit":"eef84be9-5dd8-4fd0-ac73-fe3917b05797"},"_deposit":{"created_by":1,"id":"43915","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43915"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043915","sets":["1"]},"author_link":["436562","436574","436564","436573","436563","436569","436570","436576","436577","436572","436567","436566","436568","436575","436565","436571"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"94","bibliographicPageStart":"85","bibliographicVolumeNumber":"403","bibliographic_titles":[{"bibliographic_title":"Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"3SB, a mouse thymoma cell line, is one of the most radio-sensitive cells (D0 = 0.3 Gy), and its rapid apoptosis (4 h after 5 Gy irradiation, 90% apoptosis) seems to play a decisive role in enhancing the radiosensitivity. To understand the molecular mechanisms underlying extremely high radiosensitivity and rapid apoptosis, we attempted to isolate X-ray-resistant (XR) variants from 3SBH5, a stable subclone of 3SB, by repeating exposure of the cells to 2-5 Gy X-rays. Four independent stable XR variants, R111, R223, R316 and R429, were isolated by the repeated irradiation protocols. All XR cells possessed about 3 times higher D10 values than that of their parental 3SBH5. They were also resistant to apoptosis; only 10% cells underwent apoptosis 4 h after 5 Gy irradiation. The p53 protein was induced in all the cell lines after 5 Gy X-irradiation. These variants showed a cross resistance to a chemical reagent daunorubicin (DNR) that is known to be involved in the ceramide-mediated apoptosis. DNR, as well as C2-ceramide (5 muM) induced apoptosis in parental 3SBH5 cell, but not in two XR variants, R233 and R316 cells. Present result suggests that the induction of X-ray resistance by repeated X-irradiation might be achieved, at least partly, by the enhanced resistance to the ceramide-mediated apoptosis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hama-Inaba, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"436562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"436563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"436564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsushima, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"436565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"436566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takusagawa, Mitsuko"}],"nameIdentifiers":[{"nameIdentifier":"436567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"436568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muto, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"436569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Harumi"}],"nameIdentifiers":[{"nameIdentifier":"436570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲葉 浩子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 雅彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 俊行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田草川 光子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"436577","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-12-16"},"publish_date":"2005-12-16","publish_status":"0","recid":"43915","relation_version_is_last":true,"title":["Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:21:34.813140+00:00"}