{"created":"2023-05-15T14:33:44.763131+00:00","id":43776,"links":{},"metadata":{"_buckets":{"deposit":"ee442572-e5f0-47f8-8948-dec309d933cc"},"_deposit":{"created_by":1,"id":"43776","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43776"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043776","sets":["1"]},"author_link":["435269","435273","435265","435268","435270","435274","435271","435266","435267","435272","435275"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1184","bibliographicPageStart":"1175","bibliographicVolumeNumber":"148","bibliographic_titles":[{"bibliographic_title":"Archives of Virology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ecotropic infection by Murine leukemia virus (MuLV) infection is initiated by the interaction between the receptor-binding domain of the viral surface glycoprotein (SU) and the cell-surface receptor, mCAT-1. To study the in vivo localization of viral binding site in mice, green fluorescence protein (GFP)-tagged Friend SU (F-SU/GFP) was incubated with tissue sections. Lymphohematopoietic organs and a part of the glandular tissues of C3H as well as C57BL/6 mice revealed positive signals for F-SU/GFP binding on the cell surface. In contrast, C4W mice, which is a partial congenic mouse strain carrying the Fr-4r gene on a BALB/c genetic background, exhibited negative signals in most of the organs except for a very weak binding in the pancreas. The expression of mCAT-1 mRNA determined by reverse transcriptase (RT)-polymerase chain reaction (PCR) revealed a similar distribution in C3H, C57BL/6 and C4W mice. Most of the organs including lymphohematopoietic organs and glandular organs revealed significant expression of mRNA for mCAT-1 gene, while the liver, heart and muscle did not. The results from binding assay were consistent with the fact that Friend MuLV-induced pathogenesis was usually associated with lymphohematopoietic systems, although mRNA expression for mCAT-1 was rather ubiquitous. The discrepancy between F-SU/GFP binding and mRNA expression for mCAT-1 in lymphohematopoietic organs of C4W mice would support the receptor interference effect by the Fr-4r gene causing the resistance of C4W mouse to Friend MuLV infection.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-8608","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"435265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Maki"}],"nameIdentifiers":[{"nameIdentifier":"435266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takako"}],"nameIdentifiers":[{"nameIdentifier":"435267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"435268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Shirou"}],"nameIdentifiers":[{"nameIdentifier":"435269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirokawa, Katsuiku"}],"nameIdentifiers":[{"nameIdentifier":"435270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitagawa, Masanobu"}],"nameIdentifiers":[{"nameIdentifier":"435271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口 修一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 真紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤 志郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北川 昌伸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"435275","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo distribution of receptor for ecotropic murine leukemia virus and binding of envelope protein of Friend Murine leukemia virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo distribution of receptor for ecotropic murine leukemia virus and binding of envelope protein of Friend Murine leukemia virus"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-08-18"},"publish_date":"2005-08-18","publish_status":"0","recid":"43776","relation_version_is_last":true,"title":["In vivo distribution of receptor for ecotropic murine leukemia virus and binding of envelope protein of Friend Murine leukemia virus"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:23:11.177028+00:00"}