{"created":"2023-05-15T14:33:35.022703+00:00","id":43561,"links":{},"metadata":{"_buckets":{"deposit":"311e1794-c189-4333-8a01-d38529c7ca94"},"_deposit":{"created_by":1,"id":"43561","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43561"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043561","sets":["1"]},"author_link":["433142","433146","433139","433143","433144","433141","433138","433145","433137","433147","433135","433140","433136"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"597","bibliographicPageStart":"591","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: We analyzed the death pattern of human lung cancer cells harboring different p53 statuses after irradiation with different levels of linear energy transfer (LET). METHODS AND MATERIALS: We used three kinds of human lung cancer cell lines with identical genotypes, except for the p53 gene. These cells were exposed to X-rays or accelerated carbon-ion beams. The cellular sensitivities were determined by a colony-forming assay. The detection and quantification of cell death (apoptosis and necrosis) were evaluated and compared by acridine orange/ethidium bromide double staining for fluorescence microscopy. RESULTS: We found that (1) there was no significant difference in cellular sensitivity to LET radiation >70 KeV/microm, although wild-type p53 cell sensitivity to X-rays was higher than that of mutated p53 or p53-null cells; (2) low-LET radiation effectively induced apoptosis in wild-type p53 cells as compared with mutated p53 and p53-null cells; and (3) high-LET radiation induced p53-independent apoptosis. CONCLUSIONS: Our findings suggest that high-LET radiotherapy is expected to be a valid application for patients carrying mutated p53 cancer cells. We proposed that the elucidation of the p53-independent apoptosis-related genes might provide new insights into radiotherapy for cancer.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Akihisa"}],"nameIdentifiers":[{"nameIdentifier":"433135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"433136","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Mizuho"}],"nameIdentifiers":[{"nameIdentifier":"433137","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"433138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohnishi, Ken"}],"nameIdentifiers":[{"nameIdentifier":"433139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohnishi, Takeo"}],"nameIdentifiers":[{"nameIdentifier":"433140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"433141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 昭久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 武雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433147","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-12-11"},"publish_date":"2004-12-11","publish_status":"0","recid":"43561","relation_version_is_last":true,"title":["High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:25:45.762930+00:00"}