{"created":"2023-05-15T14:33:31.827610+00:00","id":43490,"links":{},"metadata":{"_buckets":{"deposit":"c374297b-1bc7-430e-9011-e4cd770a4d6e"},"_deposit":{"created_by":1,"id":"43490","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43490"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043490","sets":["1"]},"author_link":["432487","432493","432499","432492","432491","432495","432488","432497","432498","432496","432494","432490","432489"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1528","bibliographicPageStart":"1525","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Oncology Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the effects of the farnesyl transferase inhibitor (FTI) manumycin and the MEK inhibitor PD98059 on growth of human pancreatic cancer, with mutant (SUIT2) or wild-type (BxPC-3) K-ras, xenografted into nude mice. Tumor growth was not reduced by either of the agents at a dose of 3 mg/kg without irradiation. Growth of SUIT2 irradiated at 15 Gy or 30 Gy was reduced by manumycin and PD98059: at 15 Gy, tumor volume doubling time (TVDT) increased from 18.6+/-3.8 to 36.3+/-14.2 days with PD98059 (p<0.05); at 30 Gy, TVDT increased from 32.8+/-6.8 to 70.5+/-10.5 days and 70.7+/-1.5 days, respectively. Manumycin tended to reduce growth of BxPC-3, but the difference in TVDT was not statistically significant. PD98059 significantly increased the TVDT of BxPC-3 at 30 Gy from 34.4+/-18 to 62.6+/-9.8 at 30 Gy. The present results suggest that Ras signaling pathways are potential targets for manipulation of radiosensitivity, and that induction of an alternative pathway may enhance radiosensitivity of pancreatic cancer.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1021-335X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsui, Yoshifumi"}],"nameIdentifiers":[{"nameIdentifier":"432487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gotou, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"432488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"432489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asano, Takehide"}],"nameIdentifiers":[{"nameIdentifier":"432490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanmochi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"432491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"432492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ochiai, Takenori"}],"nameIdentifiers":[{"nameIdentifier":"432493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松井 芳文","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅野 武秀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"落合 武徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432499","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-10-04"},"publish_date":"2004-10-04","publish_status":"0","recid":"43490","relation_version_is_last":true,"title":["Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:26:41.504898+00:00"}