{"created":"2023-05-15T14:33:28.688980+00:00","id":43420,"links":{},"metadata":{"_buckets":{"deposit":"9bce342e-e39c-41cc-b591-683eb5069935"},"_deposit":{"created_by":1,"id":"43420","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43420"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043420","sets":["1"]},"author_link":["431825","431820","431821","431824","431823","431822"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"399","bibliographicPageStart":"391","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Pigment Cell Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Long-term exposure of ultraviolet radiation B (UVB) induced pigmented spots in the dorsal skin of hairless mice of Hos:(HR-1 X HR/De) F1. Previous study showed that the proliferative and differentiative activities of cultured epidermal melanoblasts/melanocytes from UVB-induced pigmented spots increased with the development of the pigmented spots. To determine whether the increase in the proliferative and differentiative activities of epidermal melanoblasts/melanocytes was brought about by direct changes in melanocytes, or by indirect changes in surrounding keratinocytes, pure cultured melanoblasts/melanocytes and keratinocytes were prepared and co-cultured in combination between control and irradiated mice in a serum-free culture medium. Keratinocytes from irradiated mice stimulated the proliferation and differentiation of both neonatal and adult non-irradiated melanoblasts/melanocytes more greatly than those from adult non-irradiated mice. In contrast, both non-irradiated and irradiated adult melanocytes proliferated and differentiated similarly when they were co-cultured with irradiated adult keratinocytes. These results suggest that the increased proliferative and differentiative activities of mouse epidermal melanocytes from UVB-induced pigmented spots are regulated by keratinocytes, rather than melanocytes.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0893-5785","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirobe, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"431820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuya, Rikako"}],"nameIdentifiers":[{"nameIdentifier":"431821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akiu, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"431822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ifuku, Ouji"}],"nameIdentifiers":[{"nameIdentifier":"431823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuda, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"431824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣部 知久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431825","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-06-18"},"publish_date":"2004-06-18","publish_status":"0","recid":"43420","relation_version_is_last":true,"title":["Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:27:30.718938+00:00"}